Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 9/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171657 | 0.84 | USP30 (0.36) | KLKB1USP30SCDRIPK1RBP4 | |
| SCHEMBL5171051 | 0.81 | HRH3 (0.35) | BRD4 | |
| SCHEMBL5171317 | 0.81 | FNTA (0.35) | — | |
| SCHEMBL5172012 | 0.79 | HRH3 (0.40) | — | |
| SCHEMBL5171933 | 0.79 | HRH3 (0.41) | — | |
| SCHEMBL5169161 | 0.78 | PRMT5 (0.36) | — | |
| SCHEMBL5170173 | 0.77 | ALDH1A1 (0.34) | — | |
| SCHEMBL5661745 | 0.76 | ESR2 (0.43) | SCDRBP4 | |
| SCHEMBL5194058 | 0.76 | HRH3 (0.41) | — | |
| SCHEMBL5170182 | 0.76 | HCRTR1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |