Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177114 | 0.82 | POLB (0.43) | SIGMAR1POLBPKMLMNAMAPT | |
| SCHEMBL4321471 | 0.78 | STS (0.39) | PKMSTSMAPK1KMT2AKEAP1 | |
| SCHEMBL6535958 | 0.76 | MEN1 (0.41) | SIGMAR1POLBSTSMEN1KMT2A | |
| SCHEMBL25414924 | 0.74 | MEN1 (0.42) | MAPTMEN1KMT2A | |
| SCHEMBL4710880 | 0.73 | NR1H2 (0.39) | PKMMAPK1NR1H2OPRD1OPRK1 | |
| SCHEMBL22365602 | 0.72 | OPRD1 (0.36) | PKMSTSMAPK1MEN1KMT2A | |
| SCHEMBL28637688 | 0.72 | NR1H2 (0.40) | PKMMAPK1MEN1KMT2ANR1H2 | |
| SCHEMBL30151394 | 0.72 | NR1H2 (0.40) | PKMMAPK1NR1H2OPRD1OPRK1 | |
| SCHEMBL3733138 | 0.71 | MAPK1 (0.39) | SIGMAR1PKMMAPK1MEN1KMT2A | |
| SCHEMBL25423853 | 0.71 | MAPK1 (0.37) | PKMMAPTSTSMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |