Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30151394 | 0.82 | NR1H2 (0.40) | NR1H2NR1H3MAPK1TSHRALOX15 | |
| SCHEMBL27993675 | 0.81 | SIGMAR1 (0.39) | TSHROPRD1MEN1KMT2A | |
| SCHEMBL28139616 | 0.81 | TSHR (0.43) | NR1H2NR1H3TSHRALOX15ATM | |
| SCHEMBL4710880 | 0.81 | NR1H2 (0.39) | NR1H2NR1H3MAPK1TSHRALOX15 | |
| SCHEMBL28029544 | 0.81 | MAPK1 (0.39) | NR1H2NR1H3MAPK1TSHRGPR119 | |
| SCHEMBL27848384 | 0.81 | GPR119 (0.42) | NR1H2NR1H3MAPK1TSHRALOX15 | |
| SCHEMBL4592731 | 0.80 | SIGMAR1 (0.38) | TSHROPRD1KDM4EMEN1KMT2A | |
| SCHEMBL30893065 | 0.79 | TSHR (0.37) | NR1H2NR1H3MAPK1TSHRALOX15 | |
| SCHEMBL29091781 | 0.78 | OPRD1 (0.38) | NR1H2NR1H3MAPK1TSHRALOX15 | |
| SCHEMBL3733138 | 0.77 | MAPK1 (0.39) | NR1H2NR1H3MAPK1TSHRGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113412259-A | Bifunctional compounds for the degradation of BTK via the ubiquitin proteasome pathway | 紐力克斯治疗公司 | 2021-09-17 | — | — | CN | disclosed |