Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.37 |
| ▸ | CA6 | P23280 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641388 | 0.85 | GAA (0.39) | L3MBTL1ALDH1A1KDM4ECA1CA2 | |
| Hydrochloric Acid SCHEMBL28295364 | 0.83 | GAA (0.38) | L3MBTL1ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL15478494 | 0.83 | L3MBTL1 (0.44) | L3MBTL1ALDH1A1CA1CA2CA9 | |
| SCHEMBL8642839 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4ECA1CA2CA9 | |
| SCHEMBL7647234 | 0.81 | ALDH1A1 (0.38) | ALDH1A1KDM4ECA1CA2CA9 | |
| SCHEMBL4157506 | 0.80 | LMNA (0.47) | ALDH1A1CA2KMT2AMEN1POLB | |
| SCHEMBL7185812 | 0.79 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1KDM4ECA1CA2 | |
| SCHEMBL25519494 | 0.78 | EDNRB (0.37) | ALDH1A1KDM4ECA1CA2CA9 | |
| SCHEMBL801935 | 0.77 | ALDH1A1 (0.49) | L3MBTL1ALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL822831 | 0.77 | MAOA (0.46) | L3MBTL1ALDH1A1KDM4ECA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097141-B1 | IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR PREPARING THEM AND THEIR USE AS A DRUG OR DIAGNOSTIC AGENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-05-23 | — | — | EP | disclosed |
| CN-1231465-C | Biphenylsulfonyl cyanamides, method for the production thereof and use thereof as medicaments | AVENTIS PHARMACEUTIC DEUTSCHLA (DE) | 2005-12-14 | — | — | CN | disclosed |
| CN-1211370-C | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2005-07-20 | — | — | CN | disclosed |
| CN-1177827-C | Biphenylsulfonyl-substd. imidazole derivs., their preparation process, their use as drug or diagnostic agent and drug contg. them | ���ĵ�˹ҩ��¹�����˾ | 2004-12-01 | — | — | CN | disclosed |
| EP-1097140-B1 | BIPHENYLSULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS A DRUG OR DIAGNOSTIC AGENT AND DRUG CONTAINING THEM | AVENTIS PHARMA GMBH (DE) | 2004-03-03 | — | — | EP | disclosed |
| EP-1053224-B1 | BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT | AVENTIS PHARMA GMBH (DE) | 2002-08-21 | — | — | EP | disclosed |
| US-6372917-B1 | INHIBIT CELLULAR SODIUM ION-DEPENDENT CHLORIDE ION/BICARBONATE-EXCHANGE MECHANISM OR SODIUM/BICARBONATE SYMPORTER; TREATMENT OF ALL ACUTE OR CHRONIC DAMAGE CAUSED BY ISCHEMIA OR ILLNESSES INDUCED THEREBY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-16 | — | — | US | disclosed |
| US-6369236-B1 | DRUG FOR MEDICAL DIAGNOSIS ANTIARRHYTHMIC PROPRIETIES AND CONTAIN A CARDIOPROTECTIVE COMPOUND. THEY CAN PREVENTIVELY INHIBIT OR STRONGLY REDUCE PATHOPHYSIOLOGIC PROCESSES UPON OCCURRENCE OF ISCHEMIC INJURIES, ESPECIALLY ISCHEMIC CARDIAC | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-09 | — | — | US | disclosed |
| US-6369069-B1 | CARDIOVASCULAR DISORDERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-04-09 | — | — | US | disclosed |
| CN-1309645-A | Imidazole derivatives with biphenylsulfonyl substituents, process for their preparation and their use as pharmaceuticals or diagnostic agents | AVENTIS PHARMA GMBH (DE) | 2001-08-22 | — | — | CN | disclosed |
| EP-1097140-A2 | BIPHENYLSULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS A DRUG OR DIAGNOSTIC AGENT AND DRUG CONTAINING THEM | Aventis Pharma Deutschland GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| EP-1097141-A1 | IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR PREPARING THEM AND THEIR USE AS A DRUG OR DIAGNOSTIC AGENT | Aventis Pharma Deutschland GmbH (DE) | 2001-05-09 | — | — | EP | disclosed |
| CN-1289321-A | Biphenylsulfonyl cyanamides, method for the production thereof and their utilization as a medicament | AVENTIS PHARMACEUTIC DEUTSCHLA (DE) | 2001-03-28 | — | — | CN | disclosed |
| EP-1053224-A1 | BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT | Aventis Pharma Deutschland GmbH (DE) | 2000-11-22 | — | — | EP | disclosed |
| CN-1052720-C | New compositions of matter | RHONE POULENC AGRICULTURE (GB) | 2000-05-24 | — | — | CN | disclosed |
| WO-2000003996-A1 | IMIDAZOLE DERIVATIVES WITH BIPHENYLSULFONYL SUBSTITUTION, METHOD FOR PREPARING THEM AND THEIR USE AS A DRUG OR DIAGNOSTIC AGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| WO-2000003994-A2 | BIPHENYLSULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES, THEIR PREPARATION PROCESS, THEIR USE AS A DRUG OR DIAGNOSTIC AGENT AND DRUG CONTAINING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |
| WO-1999040064-A1 | BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-08-12 | — | — | WO | disclosed |
| CN-1038675-C | Novel herbicide and use thereof | RHONE POULENC AGRICULTURE (GB) | 1998-06-10 | — | — | CN | disclosed |
| CN-1149050-A | New compositions of matter | RHONE POULENC AGRICULTURE (GB) | 1997-05-07 | — | — | CN | disclosed |