Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | ESR1 | P03372 | 2/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 1/20 | 0.60 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.59 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174922 | 1.00 | HRH3 (0.65) | HRH3KCNH2LTA4HESR1KCNA5 | |
| SCHEMBL5176439 | 0.96 | KDR (0.65) | HRH3KCNH2LTA4HESR1KCNA5 | |
| Hydrochloric Acid SCHEMBL5176435 | 0.95 | KDR (0.64) | HRH3KCNH2LTA4HESR1KCNA5 | |
| SCHEMBL5175549 | 0.87 | KCNA5 (0.57) | HRH3KCNH2LTA4HKCNA5KDR | |
| SCHEMBL5176746 | 0.86 | HRH3 (0.60) | HRH3LTA4HKCNA5 | |
| SCHEMBL5173978 | 0.86 | EPHX2 (0.66) | HRH3KCNH2LTA4HKCNA5EPHX2 | |
| SCHEMBL5174638 | 0.85 | RAB9A (0.58) | HRH3KCNH2EPHX2HTT | |
| SCHEMBL5174741 | 0.85 | RAB9A (0.58) | HRH3KCNH2EPHX2HTT | |
| SCHEMBL5174997 | 0.85 | LTA4H (0.63) | HRH3KCNH2LTA4HKCNA5KDR | |
| SCHEMBL5175547 | 0.84 | LTA4H (0.55) | HRH3KCNH2LTA4HESR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | HRH3 159/4885KCNH2 3148/4885LTA4H 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.