SCHEMBL5174563

SCHEMBL5174563

COc1c(N)cc(N)c(C)c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.41
ACHE P22303 1/20 0.37
ALDH1A1 P00352 4/20 0.37
CYP3A4 P08684 2/20 0.37
HSD17B10 Q99714 2/20 0.34
CYP1A2 P05177 1/20 0.34
ALOX15 P16050 1/20 0.34
CASP7 P55210 1/20 0.34
HIF1A Q16665 1/20 0.34
GAA P10253 2/20 0.34
TUBB4A P04350 2/20 0.34
TUBB P07437 2/20 0.34
TUBA3C P0DPH7 2/20 0.34
TUBA1B P68363 2/20 0.34
TUBA4A P68366 2/20 0.34
TUBB4B P68371 2/20 0.34
TUBB3 Q13509 2/20 0.34
TUBB2A Q13885 2/20 0.34
TUBB8 Q3ZCM7 2/20 0.34
TUBA3E Q6PEY2 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5177958 0.90 ACHE (0.40) ACHEALDH1A1CYP3A4HSD17B10GAA
SCHEMBL3008135 0.83 IMPDH2 (0.41) IMPDH2ACHEALDH1A1CYP3A4GAA
SCHEMBL30949884 0.83 ACHE (0.46) ACHEALDH1A1CYP3A4HSD17B10GAA
SCHEMBL3005373 0.83 CYP3A4 (0.40) IMPDH2ACHEALDH1A1CYP3A4HSD17B10
Hydrochloric Acid SCHEMBL8946544 0.81 IMPDH2 (0.40) IMPDH2ACHEALDH1A1CYP3A4GAA
SCHEMBL30776799 0.76 ALDH1A1 (0.39) ACHEALDH1A1CYP3A4HSD17B10GAA
SCHEMBL27643275 0.76 ACHE (0.50) ACHEALDH1A1CYP3A4HSD17B10GAA
SCHEMBL442754 0.76 ALDH1A1 (0.39) ACHEALDH1A1CYP3A4HSD17B10GAA
SCHEMBL11307252 0.75 ALDH1A1 (0.46) ACHEALDH1A1CYP3A4HSD17B10ALOX15
Hydrochloric Acid SCHEMBL8537064 0.75 ALDH1A1 (0.37) ACHEALDH1A1CYP3A4GAATUBB4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1748822-A1 M-PHENYLENE DIAMINE COUPLING COMPONENTS Henkel Kommanditgesellschaft auf Aktien (DE) 2007-02-07 EP claimed
WO-2005117819-A1 M-PHENYLENE DIAMINE COUPLING COMPONENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2005-12-15 WO claimed
EP-1748822-A1 M-PHENYLENE DIAMINE COUPLING COMPONENTS Henkel Kommanditgesellschaft auf Aktien (DE) 2007-02-07 EP disclosed
WO-2005117819-A1 M-PHENYLENE DIAMINE COUPLING COMPONENTS HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2005-12-15 WO disclosed