Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 7/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174674 | 0.82 | EPHX1 (0.56) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10522617 | 0.74 | RAB9A (0.73) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4918739 | 0.72 | EPHX1 (0.64) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4912495 | 0.72 | CA12 (0.61) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7904577 | 0.68 | ADAM17 (0.64) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL863136 | 0.66 | NPC1 (0.66) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9208913 | 0.66 | ADAM17 (0.61) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL26333613 | 0.66 | NPC1 (0.60) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28872246 | 0.65 | NPC1 (0.64) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2731878 | 0.65 | NPC1 (0.68) | ADAM17TAAR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786422-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | Prosidion Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006018662-A2 | ARYL UREA DERIVATIVES FOR TREATING OBESITY | PROSIDION LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |