Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.66 |
| ▸ | RAB9A | P51151 | 5/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2731878 | 0.84 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL5251770 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL4031932 | 0.82 | POLB (0.69) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL885325 | 0.81 | POLB (0.68) | RAB9ASMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL6077138 | 0.81 | LMNA (0.65) | NPC1RAB9ASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7904577 | 0.81 | ADAM17 (0.64) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL3322924 | 0.81 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL26333613 | 0.81 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL28872246 | 0.81 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 | |
| SCHEMBL11842516 | 0.80 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2TAAR1ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115484933-A | Hot melt extrusion solid dispersions containing BCL2 inhibitors | 广州麓鹏制药有限公司 | 2022-12-16 | — | — | CN | disclosed |
| US-9856254-B2 | Alkoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2018-01-02 | — | — | US | disclosed |
| US-20160280707-A1 | ALKOXY SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES CO (US) | 2016-09-29 | — | — | US | disclosed |
| US-20160280707-A1 | ALKOXY SUBSTITUTED IMIDAZOQUINOLINES | 3M INNOVATIVE PROPERTIES CO (US) | 2016-09-29 | — | — | US | disclosed |
| US-9365567-B2 | Alkoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365567-B2 | Alkoxy substituted imidazoquinolines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-06-14 | — | — | US | disclosed |
| EP-1696912-B1 | PYRAZOLOPYRIDINES AND ANALOGS THEREOF | 3M INNOVATIVE PROPERTIES CO (US) | 2016-05-11 | — | — | EP | disclosed |
| US-9315454-B2 | Compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-04-19 | — | — | US | disclosed |
| WO-2016012333-A1 | PESTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-01-28 | — | — | WO | disclosed |
| US-9145410-B2 | Pyrazolopyridines and analogs thereof | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2015-09-29 | — | — | US | disclosed |
| US-4839365-A | Thienopyridine derivatives useful in treating gastric ulcers | SHINOGI & CO., LTD. (JP) | 1989-06-13 | — | — | US | disclosed |
| EP-0292051-A2 | Thienopyridine derivatives | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1988-11-23 | — | — | EP | disclosed |
| EP-0262395-A2 | Sulfonamido-ethyl compounds, medicines containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-04-06 | — | — | EP | disclosed |
| US-4517124-A | REACTION OF A MERCAPTAN TO FORM ANTIVIOTIC | BEECHAM GROUP LIMITED (GB) | 1985-05-14 | — | — | US | disclosed |
| EP-0046363-B1 | PROCESS FOR THE PREPARATION OF 2-THIO PENEM DERIVATIVES AND INTERMEDIATES THEREFOR | BEECHAM GROUP PLC (GB) | 1984-11-14 | — | — | EP | disclosed |
| EP-0005348-B1 | CARBAPENEM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1982-09-22 | — | — | EP | disclosed |
| EP-0046363-A1 | Process for the preparation of 2-thio penem derivatives and intermediates therefor | BEECHAM GROUP PLC (GB) | 1982-02-24 | — | — | EP | disclosed |
| US-4278686-A | ANTIBIOTICS | BEECHAM GROUP LIMITED (GB) | 1981-07-14 | — | — | US | disclosed |
| EP-0005349-A1 | Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates | BEECHAM GROUP PLC (GB) | 1979-11-14 | — | — | EP | disclosed |
| EP-0005348-A1 | Carbapenem derivatives, a process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1979-11-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280707-A1 | ALKOXY SUBSTITUTED IMIDAZOQUINOLINES | IL2, IFNG, IRF3 | NPC1 2931/4885RAB9A 1342/4885SMN1; SMN2 3463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.