Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 3/20 | 0.38 |
| ▸ | LDHB | P07195 | 3/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
| ▸ | GABRE | P78334 | 2/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.34 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.34 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174151 | 0.85 | ALDH1A1 (0.42) | KDM4EMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL5175754 | 0.74 | LDHA (0.33) | LDHALDHBKDM4ETDP1PSMD14 | |
| SCHEMBL4313085 | 0.74 | PPARA (0.43) | PTPN1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL6266716 | 0.73 | KAT8 (0.46) | PTPN1KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL316590 | 0.73 | KDM4E (0.40) | LDHALDHBPTPN1PTPN11KDM4E | |
| SCHEMBL5349926 | 0.73 | PRKCI (0.38) | LDHALDHBPTPN1PTPN11GABRP | |
| SCHEMBL4317058 | 0.72 | PPARA (0.45) | PTPN1MCL1PPARG | |
| SCHEMBL14989173 | 0.72 | LDHA (0.49) | LDHALDHBPTPN1PTPN11KDM4E | |
| SCHEMBL3352707 | 0.71 | ALDH1A1 (0.41) | LDHALDHBPTPN1PTPN11KDM4E | |
| SCHEMBL29240843 | 0.70 | PTPN1 (0.43) | LDHALDHBPTPN1PTPN11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740575-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108358-A2 | PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |