Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175085 | 0.74 | LDHA (0.38) | LDHALDHBKDM4EPSMD14RECQL | |
| SCHEMBL14989173 | 0.67 | LDHA (0.49) | LDHALDHBKDM4EPSMD14RECQL | |
| SCHEMBL3352707 | 0.66 | ALDH1A1 (0.41) | LDHALDHBKDM4EKMT2AALDH1A1 | |
| SCHEMBL5186125 | 0.65 | HSD17B10 (0.40) | KMT2AALDH1A1 | |
| SCHEMBL5349926 | 0.65 | PRKCI (0.38) | LDHALDHB | |
| SCHEMBL4542790 | 0.65 | F7 (0.42) | KMT2AALDH1A1 | |
| SCHEMBL5174296 | 0.64 | CFTR (0.35) | LDHALDHBKDM4EKMT2AALDH1A1 | |
| SCHEMBL9316023 | 0.64 | KMT2A (0.38) | KMT2AALDH1A1POLB | |
| SCHEMBL7558061 | 0.63 | CSNK2A1 (0.44) | KMT2AALDH1A1POLB | |
| SCHEMBL19084967 | 0.63 | CSNK2A1 (0.49) | KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740573-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005108391-A1 | AMIDES AS BACE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-11-17 | — | — | WO | disclosed |