Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.73 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.71 |
| ▸ | PSMB5 | P28074 | 5/20 | 0.71 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 2/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5943688 | 0.87 | HRH3 (0.61) | LTA4HPSMB1PSMB5KDM4EALDH1A1 | |
| SCHEMBL13305534 | 0.86 | LTA4H (0.97) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL28380360 | 0.85 | LTA4H (1.00) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL10685703 | 0.84 | LTA4H (0.70) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL10676277 | 0.83 | LTA4H (0.71) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL5175879 | 0.82 | PSMB1 (0.67) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL5175884 | 0.82 | PSMB1 (0.67) | LTA4HPSMB1PSMB5PSMB2ESR1 | |
| SCHEMBL2741667 | 0.81 | PSMB1 (0.80) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL1027972 | 0.81 | PSMB1 (0.80) | LTA4HPSMB1PSMB5PSMB2KDM4E | |
| SCHEMBL3951411 | 0.81 | LTA4H (0.83) | LTA4HPSMB1PSMB5PSMB2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | claimed |
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | LTA4H 1/4885PSMB1 1580/4885PSMB5 1646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.