Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.77 |
| ▸ | HTR2A | P28223 | 2/20 | 0.70 |
| ▸ | LTA4H | P09960 | 4/20 | 0.70 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | ADIPOR2 | Q86V24 | 1/20 | 0.57 |
| ▸ | ADIPOR1 | Q96A54 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.57 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5175893 | 0.94 | MCHR1 (0.72) | MCHR1HTR2ALTA4HCHRM1POLB | |
| SCHEMBL5943699 | 0.91 | MCHR1 (0.65) | MCHR1HTR2ALTA4HPOLBSIGMAR1 | |
| SCHEMBL5174980 | 0.90 | MCHR1 (0.65) | MCHR1HTR2ALTA4HPOLBSIGMAR1 | |
| SCHEMBL5174917 | 0.89 | LTA4H (0.70) | MCHR1HTR2ALTA4HPOLBSIGMAR1 | |
| SCHEMBL5175534 | 0.88 | POLB (0.65) | MCHR1HTR2APOLBSIGMAR1ADIPOR2 | |
| SCHEMBL5174906 | 0.85 | MCHR1 (0.61) | MCHR1HTR2ALTA4HCHRM1POLB | |
| SCHEMBL5174557 | 0.85 | SIGMAR1 (0.63) | MCHR1HTR2ALTA4HPOLBSIGMAR1 | |
| SCHEMBL3164487 | 0.85 | SIGMAR1 (0.74) | MCHR1POLBSIGMAR1 | |
| SCHEMBL5175170 | 0.83 | LTA4H (0.71) | MCHR1LTA4HPOLBSIGMAR1ADIPOR2 | |
| SCHEMBL5173905 | 0.83 | S1PR5 (0.71) | HTR2ALTA4HSIGMAR1HRH3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | claimed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | claimed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | claimed |
| EP-1868605-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006105304-A2 | PHENYL AND PYRIDYL LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | WO | disclosed |
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060223792-A1 | Phenyl and pyridyl LTA4H modulators | LTA4H, LTB4R, LTC4S | MCHR1 4089/4885HTR2A 1261/4885LTA4H 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.