Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696272 | 0.83 | CHRM1 (0.42) | LMNAGAAALDH1A1KDM4EHTT | |
| SCHEMBL1198667 | 0.73 | MEN1 (0.42) | LMNAMEN1KMT2AGABRA1GABRA5 | |
| SCHEMBL29857451 | 0.73 | DHFR (0.50) | LMNAGAAMEN1KMT2ATP53 | |
| SCHEMBL5696188 | 0.73 | DHFR (0.50) | LMNAGAAMEN1KMT2ATP53 | |
| SCHEMBL5177430 | 0.69 | MAPT (0.50) | GAAALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL3259108 | 0.68 | MEN1 (0.48) | LMNAGAAALDH1A1KDM4EHTT | |
| SCHEMBL3259104 | 0.68 | MEN1 (0.48) | LMNAGAAALDH1A1KDM4EHTT | |
| Hydrochloric Acid SCHEMBL30710330 | 0.65 | MEN1 (0.58) | GAAMEN1KMT2A | |
| SCHEMBL9567855 | 0.64 | ALDH1A1 (0.54) | LMNAGAAALDH1A1TDP1MEN1 | |
| SCHEMBL5176626 | 0.64 | ALDH1A1 (0.54) | LMNAGAAALDH1A1TDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807402-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006048308-A1 | QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS ANTIMITOTICS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAID DERIVATIVES | EMBL (DE) | 2006-05-11 | — | — | WO | disclosed |