Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29857451 | 1.00 | DHFR (0.50) | DHFRGUSBBCHEACHEKIF11 | |
| SCHEMBL5696173 | 0.84 | DHFR (0.50) | DHFRGUSBKIF11MEN1KMT2A | |
| SCHEMBL5696233 | 0.83 | DHFR (0.54) | DHFRGUSBKIF11MEN1KMT2A | |
| SCHEMBL29357488 | 0.83 | DHFR (0.54) | DHFRGUSBKIF11MEN1KMT2A | |
| SCHEMBL5696249 | 0.77 | DHFR (0.51) | DHFRGUSBKIF11 | |
| SCHEMBL5176445 | 0.77 | DHFR (0.51) | DHFRGUSBKIF11MAPK1HSD17B10 | |
| SCHEMBL5176914 | 0.73 | LMNA (0.41) | MEN1KMT2ATP53GAALMNA | |
| SCHEMBL9701173 | 0.73 | DHFR (0.62) | DHFRGUSBKIF11MAPK1HSD17B10 | |
| SCHEMBL5696167 | 0.72 | DHFR (0.57) | DHFRGUSBBCHEACHEKIF11 | |
| SCHEMBL5696196 | 0.69 | DHFR (0.51) | DHFRGUSBKIF11MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |