Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5177430 | 0.86 | MAPT (0.50) | GAAALDH1A1HTR2AHTR2CTDP1 | |
| SCHEMBL5176914 | 0.83 | LMNA (0.41) | GAAALDH1A1LMNAKDM4EHTT | |
| SCHEMBL5205016 | 0.81 | ALDH1A1 (0.46) | CHRM1GAAALDH1A1KDM4EMAPT | |
| SCHEMBL10925308 | 0.75 | CHRM1 (0.45) | CHRM1GAAALDH1A1LMNAHTT | |
| SCHEMBL23721282 | 0.74 | LMNA (0.42) | GAALMNAHTR2AHTR2CMAPT | |
| SCHEMBL5696173 | 0.73 | DHFR (0.50) | ALDH1A1HTTHTR2AHTR2CMAPT | |
| SCHEMBL5178013 | 0.72 | KMT2A (0.55) | GAAALDH1A1LMNAKDM4EHTT | |
| SCHEMBL4590461 | 0.71 | CACNB4 (0.47) | LMNAMAPTTP53CYP1A2CYP2C9 | |
| SCHEMBL11083785 | 0.70 | CHRM1 (0.41) | CHRM1GAAALDH1A1LMNAHTT | |
| SCHEMBL7313268 | 0.70 | HTR2C (0.39) | CHRM1GAAHTR2AHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655289-A1 | Quinazoline derivatives, process for their preparation, their use as antimitotics and pharmaceutical compositions comprising said derivatives | EMBL (DE) | 2006-05-10 | — | — | EP | disclosed |