SCHEMBL5177770

SCHEMBL5177770

CC(C)(C)OC(=O)N[C@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 12/20 0.60
THRA P10827 8/20 0.60
PCNA P12004 6/20 0.60
LMNA P02545 5/20 0.60
MEN1 O00255 4/20 0.60
KMT2A Q03164 4/20 0.60
ABCB11 O95342 2/20 0.60
GABRA1 P14867 2/20 0.60
PPARG P37231 2/20 0.60
GABRA2 P47869 2/20 0.60
GABRB2 P47870 2/20 0.60
CYP2D6 P10635 1/20 0.60
TSHR P16473 1/20 0.60
GABRP O00591 1/20 0.60
GABRD O14764 1/20 0.60
F2 P00734 1/20 0.60
GABRB1 P18505 1/20 0.60
GABRG2 P18507 1/20 0.60
GABRB3 P28472 1/20 0.60
ADORA1 P30542 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8205060 1.00 THRB (0.60) THRBTHRAPCNALMNAMEN1
SCHEMBL5177146 1.00 THRB (0.60) THRBTHRAPCNALMNAMEN1
SCHEMBL14509290 0.91 THRB (0.55) THRBTHRAPCNALMNAMEN1
SCHEMBL13670909 0.90 PCNA (0.58) THRBTHRAPCNALMNACYP2D6
SCHEMBL5177663 0.90 PCNA (0.58) THRBTHRAPCNALMNACYP2D6
SCHEMBL5177568 0.90 PCNA (0.58) THRBTHRAPCNALMNACYP2D6
SCHEMBL1526069 0.89 THRB (0.59) THRBTHRAPCNALMNAMEN1
SCHEMBL8417806 0.89 THRB (0.59) THRBTHRAPCNALMNAMEN1
SCHEMBL10780803 0.89 THRB (0.59) THRBTHRAPCNALMNAMEN1
SCHEMBL24489644 0.87 FOLH1 (0.62) PPARGITGB3ITGA2BACEFOLH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7271009-B1 Multi-analyte diagnostic test for thyroid disorders BIO-RAD LABORATORIES, INC. (US) 2007-09-18 US claimed
EP-1272855-B1 MULTI-ANALYTE DIAGNOSTIC TEST FOR THYROID DISORDERS BIO RAD LABORATORIES (US) 2007-06-06 EP claimed
US-20030054571-A1 Multi-analyte diagnostic test for thyroid disorders BIO-RAD LABORATORIES, INC. (US) 2003-03-20 US claimed
EP-1272855-A2 MULTI-ANALYTE DIAGNOSTIC TEST FOR THYROID DISORDERS BIO-RAD LABORATORIES, INC. (US) 2003-01-08 EP claimed
WO-2001079844-A2 MULTI-ANALYTE DIAGNOSTIC TEST FOR THYROID DISORDERS BIO-RAD LABORATORIES, INC. (US) 2001-10-25 WO claimed
US-20240057599-A1 METHODS FOR IMPROVING FRUIT QUALITY THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (IL) 2024-02-22 US disclosed
US-11812746-B2 Method of controlling fungal infections in plants THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (IL) 2023-11-14 US disclosed
US-11690818-B2 Drug containing liver targeting specific ligand and thyroid hormone receptor agonist KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-07-04 US disclosed
US-11690818-B2 Drug containing liver targeting specific ligand and thyroid hormone receptor agonist KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2023-07-04 US disclosed
US-20200383327-A1 METHOD OF IMPROVING PLANT PERFORMANCE THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) (IL) 2020-12-10 US disclosed
US-20190246639-A1 METHOD OF CONTROLLING FUNGAL INFECTIONS IN PLANTS THE STATE OF ISRAEL, MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCHORGANIZATION (ARO) (VOLCANI CENTER) (IL) 2019-08-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11690818-B2 Drug containing liver targeting specific ligand and thyroid hormone receptor agonist THRA, THRB, TSHR THRB 2/4885THRA 1/4885PCNA 4856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.