Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2481928 | 0.86 | TRPM8 (0.40) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL6235069 | 0.85 | TRPM8 (0.39) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL10949151 | 0.84 | KCNA5 (0.49) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL1903958 | 0.82 | KCNA5 (0.39) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL589762 | 0.82 | CYP19A1 (0.45) | TRPM8TRPA1ALDH1A1KCNA5LMNA | |
| SCHEMBL8470258 | 0.81 | KCNA5 (0.38) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL31752406 | 0.80 | TRPM8 (0.46) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL10363050 | 0.79 | KCNA5 (0.42) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL10363049 | 0.79 | KCNA5 (0.42) | TRPM8TRPA1ALDH1A1HPGDKCNA5 | |
| SCHEMBL1757998 | 0.77 | KCNA5 (0.33) | TRPM8TRPA1ALDH1A1KCNA5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534346-A4 | TOLUIDINE BLUE O DRUG SUBSTANCE AND USE THEREOF FOR IN VIVO STAINING AND CHEMOTHERAPEUTIC TREATMENT OF DYSPLASTIC TISSUES | ZILA INC (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060110326-A1 | Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues | ZILA, INC. (US) | 2006-05-25 | — | — | US | disclosed |
| EP-1534346-A2 | TOLUIDINE BLUE O DRUG SUBSTANCE AND USE THEREOF FOR IN VIVO STAINING AND CHEMOTHERAPEUTIC TREATMENT OF DYSPLASTIC TISSUES | Zila Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2003103569-A3 | TOLUIDINE BLUE O DRUG SUBSTANCE AND USE THEREOF FOR IN VIVO STAINING AND CHEMOTHERAPEUTIC TREATMENT OF DYSPLASTIC TISSUES | OKOLOTOWICZ KARL (US) | 2004-05-21 | — | — | WO | disclosed |
| WO-2003103569-A2 | TOLUIDINE BLUE O DRUG SUBSTANCE AND USE THEREOF FOR IN VIVO STAINING AND CHEMOTHERAPEUTIC TREATMENT OF DYSPLASTIC TISSUES | ZILA INC. (US) | 2003-12-18 | — | — | WO | disclosed |
| US-5019453-A | Composite material and method of making same | LOCKHEED MARTIN CORPORATION | 1991-05-28 | — | — | US | disclosed |
| US-4992335-A | Composite material and method of making same | SANDERS ASSOCIATES, INC. (US) | 1991-02-12 | — | — | US | disclosed |
| US-4935308-A | Composite material and method of making same | SANDERS ASSOCIATES (US) | 1990-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060110326-A1 | Toluidine blue o drug substance and use thereof for in vitro staining and chemotherapeutic treatment of dysplastic tissues | TPMT, DNER, INMT | TRPM8 666/4885TRPA1 1159/4885ALDH1A1 551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.