Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | KCNK13 | Q9HB14 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199874 | 0.73 | SCN9A (0.33) | SCN9AKCNK13 | |
| SCHEMBL19584694 | 0.72 | F2RL1 (0.37) | SCN9A | |
| SCHEMBL37815 | 0.71 | KDM4E (0.54) | — | |
| SCHEMBL69569 | 0.71 | — | — | |
| SCHEMBL648786 | 0.70 | SCN9A (0.53) | SCN9AHDAC4FAAHEDNRBEDNRA | |
| SCHEMBL22388750 | 0.69 | SCN9A (0.37) | SCN9AHDAC4KCNK13 | |
| SCHEMBL115447 | 0.69 | CYP3A4 (0.33) | — | |
| SCHEMBL26259957 | 0.68 | SCN9A (0.44) | SCN9AHDAC4KCNK13FAAHEDNRB | |
| SCHEMBL467328 | 0.68 | MDM2 (0.35) | — | |
| SCHEMBL18543166 | 0.68 | SCN9A (0.44) | SCN9AHDAC4EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799637-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | Amgen, Inc (US) | 2007-06-27 | — | — | EP | claimed |
| WO-2006036664-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | claimed |
| EP-1799637-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | Amgen, Inc (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006036664-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |