Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | LSS | P48449 | 1/20 | 0.46 |
| ▸ | GPR183 | P32249 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6622388 | 0.86 | DRD2 (0.54) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL6625191 | 0.81 | KDM4E (0.59) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL6624933 | 0.76 | DRD2 (0.56) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL9513241 | 0.76 | THRB (0.82) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL9512997 | 0.76 | THRB (0.73) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL11169556 | 0.74 | KMT2A (0.61) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL5084416 | 0.74 | CHRNA7 (0.54) | KDM4EALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL10898714 | 0.73 | THRB (0.73) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL5240284 | 0.73 | KCNA5 (0.55) | KDM4EALDH1A1MAPTTHRBKMT2A | |
| SCHEMBL5242494 | 0.73 | KCNA5 (0.55) | KDM4EALDH1A1MAPTTHRBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1729762-A4 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORP (US) | 2007-12-19 | — | — | EP | disclosed |
| EP-1729762-A2 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORPORATION (US) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005094305-A2 | COMBINATION THERAPY FOR WEIGHT MANAGEMENT | NEUROGEN CORPORATION (US) | 2005-10-13 | — | — | WO | disclosed |