Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 3/20 | 0.37 |
| ▸ | KIF11 | P52732 | 3/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.37 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5186063 | 0.89 | RXRA (0.40) | EPHX2KIF11ALDH1A1 | |
| SCHEMBL5187403 | 0.87 | HDAC4 (0.43) | CA12CA9EPHX2NR1H4P2RY14 | |
| SCHEMBL5186061 | 0.86 | KIF11 (0.36) | CA2P2RY14KIF11RORC | |
| SCHEMBL6561643 | 0.84 | ALDH1A1 (0.39) | CA12CA1CA2CA9KIF11 | |
| SCHEMBL5186197 | 0.83 | KIF11 (0.41) | KIF11ALDH1A1SMN1; SMN2 | |
| SCHEMBL5186164 | 0.82 | KIF11 (0.50) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6155949 | 0.82 | KIF11 (0.50) | CA12CA1CA2CA9CA14 | |
| SCHEMBL6155989 | 0.82 | KIF11 (0.50) | CA12CA1CA2CA9CA14 | |
| SCHEMBL5186003 | 0.82 | HPGD (0.47) | ALDH1A1MAPK1SMN1; SMN2KDM4E | |
| SCHEMBL5186190 | 0.81 | GRIA4 (0.44) | CA12CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183232-B1 | MONOFLUOROALKYL DERIVATIVES | LILLY CO ELI (US) | 2007-10-03 | — | — | EP | claimed |