Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.65 |
| ▸ | DRD3 | P35462 | 11/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR7 | P34969 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5185969 | 0.86 | DRD2 (0.59) | DRD2DRD3HTR7HTR1AHTR2A | |
| SCHEMBL21802149 | 0.84 | DRD2 (0.60) | DRD2DRD3ADRA1AHRH4HTR7 | |
| SCHEMBL7517458 | 0.84 | DRD2 (0.52) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Bromide SCHEMBL7527584 | 0.83 | DRD2 (0.51) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL5185914 | 0.79 | HTR1A (0.56) | DRD2DRD3HTR7HTR1AHTR2A | |
| SCHEMBL4928954 | 0.79 | DRD2 (1.00) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL5188385 | 0.78 | DRD2 (0.53) | DRD2DRD3ADRA1AHTR7HTR1A | |
| SCHEMBL4925478 | 0.78 | DRD2 (1.00) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| Hydrochloric Acid SCHEMBL4933186 | 0.77 | DRD2 (0.98) | DRD2DRD3ADRA1AHRH4SIGMAR1 | |
| SCHEMBL7518692 | 0.77 | SLC27A1 (0.48) | DRD2DRD3SIGMAR1HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325917-B1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA NV (BE) | 2007-01-03 | — | — | EP | disclosed |
| EP-0912533-B1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2004-09-29 | — | — | EP | disclosed |
| EP-1325917-A1 | Radiolabelled alkylamino-benzothiazole and -benzoxazole derivatives and their use as D4 ligands | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-09 | — | — | EP | disclosed |
| US-6224849-B1 | Alkylaminobenzothiazole and-benzoxazole derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-05-01 | — | — | US | disclosed |
| US-6103725-A | HIGH AFFINITY TO THE DOPAMINE D4 RECEPTOR; ANTAGONISTS; ANTIPSYCHOTIC AGENTS, E.G. SCHIZOPHRENIA, WITH REDUCED SIDE-EFFECTS; ANTIPSYCHOTIC AGENTS; ANXIOLYTIC AND ANTIEMETIC AGENTS; MOTORIC FUNCTIONS, ADDICTION, SLEEP, FEEDING | JANSSEN PHARMACEUTICA, N.V. (BE) | 2000-08-15 | — | — | US | disclosed |
| EP-0912533-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997043271-A1 | ALKYLAMINOBENZOTHIAZOLE AND -BENZOXAZOLE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-11-20 | — | — | WO | disclosed |