SCHEMBL5187348

SCHEMBL5187348

O=C(O)c1ccc2c3ccc(C(=O)NCCc4ccccc4)c4c(C(=O)NCCc5ccccc5)ccc(c5ccc(C(=O)O)c1c25)c43

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.56
NPC1 O15118 7/20 0.56
LMNA P02545 1/20 0.56
MAPT P10636 1/20 0.56
KDM4E B2RXH2 1/20 0.50
ALDH1A1 P00352 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
EGLN1 Q9GZT9 1/20 0.49
CA12 O43570 1/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
MMP1 P03956 1/20 0.49
MMP2 P08253 1/20 0.49
MMP3 P08254 1/20 0.49
CA9 Q16790 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL823219 1.00 RAB9A (0.56) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL16351643 1.00 RAB9A (0.56) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL5051133 0.95 KMT2A (0.56) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL16351644 0.95 KMT2A (0.56) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL16352053 0.94 RAB9A (0.62) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL822668 0.94 RAB9A (0.62) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL3796253 0.94 RAB9A (0.62) RAB9ANPC1LMNAMAPTALDH1A1
SCHEMBL29705135 0.92 EGLN1 (0.49) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL12038225 0.90 MAPT (0.47) RAB9ANPC1LMNAMAPTKDM4E
SCHEMBL16351306 0.90 PLAAT3 (0.48) RAB9ANPC1LMNAMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6319645-B1 USEFUL IN ELECTROPHOTOGRAPHIC IMAGING AND PRINTING XEROX CORPORATION 2001-11-20 US claimed
JP-9015889-A None JP disclosed
JP-9015883-A None JP disclosed
JP-8320584-A None JP disclosed
EP-1235117-B1 Imaging members XEROX CORP (US) 2007-07-11 EP disclosed
EP-1235117-A1 Imaging members Xerox Corporation (US) 2002-08-28 EP disclosed
US-6319645-B1 USEFUL IN ELECTROPHOTOGRAPHIC IMAGING AND PRINTING XEROX CORPORATION 2001-11-20 US disclosed
JP-H0915883-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR NEC CORP 1997-01-17 JP disclosed
JP-H0915889-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR NEC CORP 1997-01-17 JP disclosed
JP-H08320584-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR NEC CORP 1996-12-03 JP disclosed