Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435001 | 0.79 | LRRK2 (0.39) | ALDH1A1HPGDHSD17B10MAPK1TNF | |
| SCHEMBL435161 | 0.77 | RAB9A (0.39) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL7668307 | 0.76 | ENPP1 (0.43) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL668822 | 0.75 | ALDH1A1 (0.42) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Biphenyl SCHEMBL1073325 | 0.74 | ALDH1A1 (0.55) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Biphenyl SCHEMBL28372188 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL4724144 | 0.72 | ALDH1A1 (0.41) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL25668518 | 0.72 | MAPT (0.59) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| SCHEMBL25668514 | 0.72 | MAPT (0.59) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 | |
| Benzene SCHEMBL28202246 | 0.72 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633354-A2 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-03-15 | — | — | EP | claimed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | claimed |
| WO-2004092146-A2 | N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-10-28 | — | — | WO | claimed |
| EP-1805136-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050097-A1 | SUBSTITUTED PHENYLALKANOIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060100251-A1 | Substituted phenylalkanoic acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC | 2006-05-11 | — | — | US | disclosed |
| EP-1633354-A2 | N-(((((1,3-THIAZOL-2-YL)AMINO)CARBONYL)PHENYL)SULFONYL)PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-03-15 | — | — | EP | disclosed |
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-09 | — | — | US | disclosed |
| WO-2004092146-A2 | N- (((((1,3-THIAZOL-2-YL) AMINO) CARBONYL) PHENYL) SULFONYL) PHENYLALANINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF DIABETES | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248937-A1 | Substituted phenylalkanoic acids for the treatment of diabetes | PTP4A1, PTPRJ, PPM1B | ALDH1A1 123/4885KDM4E 1445/4885MAPT 1488/4885 |
| US-20060100251-A1 | Substituted phenylalkanoic acids | PTPRJ, PTP4A1, PTPN1 | ALDH1A1 211/4885KDM4E 1607/4885MAPT 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.