Propiolactone

Propiolactone

SCHEMBL5190919

Cc1cccc2sc3ccccc3c(=O)c12.O=C1CCO1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.48
ALDH1A1 P00352 5/20 0.48
POLB P06746 3/20 0.48
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
GAA P10253 2/20 0.48
NPC1 O15118 2/20 0.45
RAB9A P51151 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45
L3MBTL1 Q9Y468 3/20 0.43
HCRTR1 O43613 1/20 0.43
LMNA P02545 1/20 0.43
MAOA P21397 2/20 0.41
MAOB P27338 1/20 0.41
APP P05067 3/20 0.39
CHRM2 P08172 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL425780 0.88 MAPT (0.58) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL31379948 0.88 MAPT (0.58) MAPTALDH1A1POLBMEN1KMT2A
Propiolactone SCHEMBL4601111 0.82 NPC1 (0.58) MAPTALDH1A1POLBMEN1KMT2A
Acetic Acid SCHEMBL31415896 0.81 MAPT (0.55) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL2542231 0.76 GPR3 (0.56) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL29402827 0.72 MAPT (0.63) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL530095 0.72 MAPT (0.63) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL1042694 0.72 MAPT (0.64) MAPTALDH1A1POLBMEN1KMT2A
SCHEMBL10059336 0.72 MAPT (0.58) MAPTALDH1A1POLBMEN1KMT2A
Propiolactone SCHEMBL6691395 0.71 NPC1 (0.79) MAPTALDH1A1MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1794240-A1 USE OF PYRIMIDO[5,4-G]PTERIDINES AS SHADING COMPONENT IN COLOR FILTER COLORANT COMPOSITIONS Ciba Specialty Chemicals Holding Inc. (CH) 2007-06-13 EP disclosed
EP-1769286-A2 OXIME DERIVATIVES AND THE USE THEROF AS LATENT ACIDS Ciba Specialty Chemicals Holding Inc. (CH) 2007-04-04 EP disclosed
WO-2006037728-A1 USE OF PYRIMIDO[5,4-G]PTERIDINES AS SHADING COMPONENT IN COLOR FILTER COLORANT COMPOSITIONS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-04-13 WO disclosed
WO-2006008250-A2 OXIME DERIVATIVES AND THE USE THEROF AS LATENT ACIDS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-01-26 WO disclosed