Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 10/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193628 | 0.89 | NQO1 (0.43) | NQO1ADORA3CYP2C9KDM4EALDH1A1 | |
| SCHEMBL14170203 | 0.88 | NQO1 (0.55) | NQO1ADORA3CYP2C9VKORC1KDM4E | |
| SCHEMBL14169946 | 0.84 | NQO1 (0.65) | NQO1ADORA3CYP2C9KDM4EALDH1A1 | |
| SCHEMBL14170049 | 0.83 | NQO1 (0.60) | NQO1CYP2C9VKORC1KDM4EALDH1A1 | |
| SCHEMBL14169934 | 0.82 | NQO1 (0.57) | NQO1ADORA3CYP2C9VKORC1KDM4E | |
| SCHEMBL14170269 | 0.80 | ADORA3 (0.54) | NQO1ADORA3CYP2C9VKORC1KDM4E | |
| SCHEMBL11882713 | 0.79 | NQO1 (0.67) | NQO1CYP2C9KDM4EALDH1A1HSD17B10 | |
| SCHEMBL14172149 | 0.79 | NQO1 (0.55) | NQO1ADORA3CYP2C9VKORC1 | |
| SCHEMBL14171314 | 0.78 | NQO1 (0.69) | NQO1CYP2C9KDM4EALDH1A1MEN1 | |
| SCHEMBL14169803 | 0.77 | CYP2C9 (0.53) | NQO1ADORA3CYP2C9VKORC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2008-06-26 | — | — | US | disclosed |
| EP-1846428-A1 | ANTI-INFLAMMATORY CONJUGATES OF MACROLIDES AND COUMARINS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006092739-A1 | ANTI-INFLAMMATORY CONJUGATES OF MACROLIDES AND COUMARINS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080153872-A1 | Bis-(Coumarin) Compounds With Anti-Inflammatory Activity | NOD1, NOD2, CASP1 | NQO1 397/4885ADORA3 2675/4885CYP2C9 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.