Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5192295 | 0.78 | CCR2 (0.41) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL8120752 | 0.77 | GHSR (0.45) | ALDH1A1HPGDMAPT | |
| SCHEMBL6297588 | 0.76 | ALDH1A1 (0.81) | ALDH1A1HTTPOLBKMT2AMEN1 | |
| SCHEMBL7259516 | 0.74 | EPHX2 (0.61) | POLBKMT2ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL2029199 | 0.74 | EPHX2 (0.61) | POLBKMT2ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL5193935 | 0.73 | L3MBTL1 (0.41) | ALDH1A1HTTPOLBHPGDNPC1 | |
| SCHEMBL25079322 | 0.73 | CHRM5 (0.41) | ALDH1A1HTTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20456249 | 0.72 | SMN1; SMN2 (0.65) | ALDH1A1HTTPOLBKMT2AMEN1 | |
| SCHEMBL466055 | 0.72 | POLB (0.51) | POLBKMT2ANPC1RAB9A | |
| SCHEMBL5192074 | 0.71 | KMT2A (0.49) | ALDH1A1HTTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |