Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5170957 | 0.91 | CHRNB2 (0.38) | HRH3GRM5GABRA5CHRNB2CHRNA7 | |
| SCHEMBL5171939 | 0.89 | HRH3 (0.40) | HRH3 | |
| SCHEMBL5169168 | 0.88 | PRMT5 (0.37) | HRH3 | |
| SCHEMBL6223629 | 0.88 | HRH3 (0.54) | HRH3OPRM1OPRD1 | |
| SCHEMBL5172025 | 0.87 | HRH3 (0.39) | HRH3 | |
| SCHEMBL5194058 | 0.85 | HRH3 (0.41) | HRH3GRM5GABRA5CHRNB2CHRNA7 | |
| SCHEMBL5171948 | 0.83 | SLC18A2 (0.33) | HRH3 | |
| SCHEMBL6225071 | 0.82 | HRH3 (0.42) | HRH3OPRM1OPRD1 | |
| SCHEMBL5171053 | 0.80 | HRH3 (0.35) | HRH3 | |
| SCHEMBL5713479 | 0.78 | HRH3 (0.46) | HRH3OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |