Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 3/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171939 | 0.89 | HRH3 (0.40) | HRH3GABRA1GRIN1GRIN2BGHSR | |
| SCHEMBL5184067 | 0.88 | GRIN1 (0.34) | GABRA1ENPP2GRIN1GRIN2BGHSR | |
| SCHEMBL5194064 | 0.87 | HRH3 (0.40) | HRH3 | |
| SCHEMBL5172012 | 0.85 | HRH3 (0.40) | HRH3GABRA1ENPP2GRIN1GRIN2B | |
| SCHEMBL5171053 | 0.81 | HRH3 (0.35) | HRH3 | |
| SCHEMBL5171948 | 0.81 | SLC18A2 (0.33) | HRH3GRIN1GRIN2BGHSRS1PR1 | |
| SCHEMBL5170957 | 0.81 | CHRNB2 (0.38) | HRH3GHSR | |
| SCHEMBL5171657 | 0.80 | USP30 (0.36) | — | |
| SCHEMBL5169168 | 0.78 | PRMT5 (0.37) | HRH3GHSR | |
| SCHEMBL5660371 | 0.77 | HRH3 (0.48) | HRH3GABRA1S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778643-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018260-A1 | TETRAHYDROBENZAZEPINES AS ANTAGONISTS AND/OR REVERSE AGONISTS OF THE HISTAMINE H 3 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |