Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | TOP1 | P11387 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17840160 | 0.75 | KIF11 (0.68) | KIF11BACE1MAOBTOP1KDM4E | |
| SCHEMBL1345566 | 0.75 | — | — | |
| SCHEMBL30759017 | 0.75 | — | — | |
| SCHEMBL18587184 | 0.74 | NTRK1 (0.46) | NTRK1KIF11TOP1APPCLK1 | |
| SCHEMBL4597238 | 0.73 | PSEN1 (0.51) | KIF11PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2841464 | 0.73 | ALDH1A1 (0.58) | KIF11PIK3R1PIK3CABACE1MAOB | |
| SCHEMBL30053194 | 0.73 | ALDH1A1 (0.58) | KIF11PIK3R1PIK3CABACE1MAOB | |
| SCHEMBL5695818 | 0.73 | KIF11 (0.56) | NTRK1KIF11BACE1MAOBTOP1 | |
| SCHEMBL30116692 | 0.73 | PTPN5 (0.38) | KIF11BACE1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL3544291 | 0.73 | PTPN5 (0.38) | KIF11BACE1KDM4ENPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773315-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006008558-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-26 | — | — | WO | disclosed |