SCHEMBL2841464

SCHEMBL2841464

FC(F)(F)c1ccc(-c2ccccc2Br)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.58
MAPK1 P28482 1/20 0.58
KIF11 P52732 7/20 0.56
BACE1 P56817 2/20 0.47
TSHR P16473 1/20 0.46
ENPP1 P22413 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
KDM4E B2RXH2 1/20 0.42
CYP1A2 P05177 1/20 0.42
POLB P06746 1/20 0.42
CYP2C19 P33261 1/20 0.42
HSD17B10 Q99714 1/20 0.42
PIK3R1 P27986 1/20 0.42
PIK3CA P42336 1/20 0.42
MAOB P27338 1/20 0.41
CHUK O15111 1/20 0.41
TXNRD1 Q16881 1/20 0.41
NOX4 Q9NPH5 1/20 0.41
JAK2 O60674 1/20 0.41
HSD11B1 P28845 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30053194 1.00 ALDH1A1 (0.58) ALDH1A1MAPK1KIF11BACE1TSHR
SCHEMBL12403034 0.85 KIF11 (0.48) ALDH1A1MAPK1KIF11BACE1TSHR
SCHEMBL17840160 0.84 KIF11 (0.68) ALDH1A1KIF11BACE1TSHRKDM4E
SCHEMBL8025255 0.82 KIF11 (0.65) ALDH1A1KIF11BACE1TSHRKDM4E
SCHEMBL12489603 0.82 ALDH1A1 (0.83) ALDH1A1MAPK1TSHRSMN1; SMN2KDM4E
SCHEMBL29016557 0.81 KIF11 (0.44) ALDH1A1MAPK1KIF11BACE1TSHR
SCHEMBL3385529 0.81 ALDH1A1 (0.50) ALDH1A1MAPK1
SCHEMBL11310344 0.80 KIF11 (0.77) ALDH1A1KIF11BACE1TSHRSMN1; SMN2
SCHEMBL370544 0.79 ALDH1A1 (0.58) ALDH1A1MAPK1KIF11TSHRSMN1; SMN2
SCHEMBL27926095 0.79 ALDH1A1 (0.52) ALDH1A1MAPK1TSHRSMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260035339-A1 TETRAHYDRONAPHTHALENE DERIVATIVE ATRANSEN PHARMA LTD (JP) 2026-02-05 US disclosed
EP-4501906-A1 TETRAHYDRONAPHTHALENE DERIVATIVE Atransen Pharma Ltd. (JP) 2025-02-05 EP disclosed
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-09-28 US disclosed
US-20230250077-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2023-08-10 US disclosed
US-20230250077-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) 2023-08-10 US disclosed
EP-4180422-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) 2023-05-17 EP disclosed
EP-4180422-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) 2023-05-17 EP disclosed
CN-112552279-B Synthesis method of substituted dibenzothiophene compound 郑州海阔光电材料有限公司 2023-02-24 CN disclosed
EP-4122934-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE Beijing Summer Sprout Technology Co., Ltd. (CN) 2023-01-25 EP disclosed
WO-2022007940-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF 江苏恒瑞医药股份有限公司 2022-01-13 WO disclosed
US-6946560-B2 Ligands for metals and improved metal-catalyzed processes based thereon MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2005-09-20 US disclosed
EP-1473297-A1 PROCESS FOR PRODUCING TERTIARY PHOSPHINE HAVING BULKY HYDROCARBON GROUP BONDED HOKKO CHEMICAL INDUSTRY CO. LTD. (JP) 2004-11-03 EP disclosed
US-20040171833-A1 Ligands for metals and improved metal-catalyzed processes based thereon NATIONAL SCIENCE FOUNDATION 2004-09-02 US disclosed
WO-2004052939-A2 LIGANDS FOR METALS AND IMPROVED METAL-CATALYZED PROCESSES BASED THEREON MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2004-06-24 WO disclosed
US-20040010149-A1 Ligands for metals and improved metal-catalyzed processes based thereon NATIONAL SCIENCE FOUNDATION 2004-01-15 US disclosed
EP-1354887-A1 Ligands for metals and improved metal-catalyzed processes based thereon Massachusetts Insitute of Technology (US) 2003-10-22 EP disclosed
US-20020156295-A1 Ligands for metals and improved metal-catalyzed processes based thereon NATIONAL SCIENCE FOUNDATION 2002-10-24 US disclosed
US-6307087-B1 USE OF CATALYSTS COMPRISING THESE LIGANDS IN TRANSITION METAL-CATALYZED CARBON-HETEROATOM AND CARBON-CARBON BOND-FORMING REACTIONS. MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2001-10-23 US disclosed
EP-1097158-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2001-05-09 EP disclosed
WO-2000002887-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-01-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040010149-A1 Ligands for metals and improved metal-catalyzed processes based thereon THEM6, SOD1, SLC30A6 ALDH1A1 2074/4885MAPK1 4255/4885KIF11 3933/4885
US-20040171833-A1 Ligands for metals and improved metal-catalyzed processes based thereon THEM6, SLC30A6, SOD1 ALDH1A1 1766/4885MAPK1 4486/4885KIF11 3942/4885
US-20020156295-A1 Ligands for metals and improved metal-catalyzed processes based thereon THEM6, SOD1, SLC30A6 ALDH1A1 2074/4885MAPK1 4255/4885KIF11 3933/4885
US-20230309388-A1 ORGANIC ELECTROLUMINESCENT MATERIAL AND DEVICE OCIAD1, OCIAD2, SLCO4C1 ALDH1A1 457/4885MAPK1 382/4885KIF11 755/4885
US-20260035339-A1 TETRAHYDRONAPHTHALENE DERIVATIVE LATS1, LATS2, BCAT1 ALDH1A1 1267/4885MAPK1 152/4885KIF11 2339/4885
US-20230250077-A1 SULFONYLBENZAMIDE DERIVATIVE AND CONJUGATE THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF GLP1R, HADHB, SUCNR1 ALDH1A1 226/4885MAPK1 2359/4885KIF11 1581/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.