Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dyphylline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.86 |
| ▸ | LMNA | P02545 | 4/20 | 0.86 |
| ▸ | POLB | P06746 | 2/20 | 0.86 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyphylline SCHEMBL8192 | 0.93 | LMNA (1.00) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL123781 | 0.93 | LMNA (1.00) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL1816552 | 0.93 | LMNA (1.00) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL27937456 | 0.91 | LMNA (0.97) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL28299816 | 0.88 | LMNA (0.90) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL13724353 | 0.88 | LMNA (0.90) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL5194181 | 0.88 | LMNA (0.90) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| SCHEMBL10063431 | 0.85 | LMNA (0.80) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| SCHEMBL5265296 | 0.83 | LMNA (0.81) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL10890402 | 0.82 | LMNA (0.78) | SMN1; SMN2LMNAPOLBADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5565462-A | PENTOXIFYLLINE, PROPENTOFYLLINE AND(OR) TORBAFYLLINE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1996-10-15 | — | — | US | disclosed |