SCHEMBL5195380

SCHEMBL5195380

c1ccc2cc(CN3CCCCC3)ccc2c1

nearest known ligand 0.74

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.74
CHKA P35790 1/20 0.71
HRH3 Q9Y5N1 3/20 0.67
ACHE P22303 1/20 0.66
PKM P14618 1/20 0.66
MC4R P32245 1/20 0.60
MC5R P33032 1/20 0.60
POLB P06746 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
ALDH1A1 P00352 1/20 0.56
HTT P42858 1/20 0.56
HRH4 Q9H3N8 1/20 0.55
OPRL1 P41146 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C19 P33261 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31010303 1.00 KMT2A (0.74) KMT2ACHKAHRH3ACHEPKM
Hydrochloric Acid SCHEMBL16825143 0.98 KMT2A (0.72) KMT2ACHKAHRH3ACHEPKM
SCHEMBL31097161 0.98 KMT2A (0.77) KMT2ACHKAHRH3ACHEPKM
SCHEMBL31392631 0.94 CHKA (0.79) KMT2ACHKAHRH3ACHEPKM
SCHEMBL27999347 0.90 KMT2A (0.89) KMT2ACHKAHRH3ACHEPKM
SCHEMBL8852275 0.89 CHKA (0.67) KMT2ACHKAHRH3ACHEPKM
SCHEMBL4750742 0.85 KMT2A (1.00) KMT2ACHKAACHEPKMMC4R
SCHEMBL13940581 0.85 CHKA (0.76) KMT2ACHKAHRH3ACHEPKM
SCHEMBL10135595 0.84 SLC6A4 (0.64) KMT2ACHKAHRH3ACHEPKM
SCHEMBL6377576 0.84 KMT2A (0.72) KMT2ACHKAHRH3ACHEPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250186981-A1 CATALYST COMPOSITION FOR CYCLIC OLEFIN POLYMERIZATION, AND METHOD FOR PREPARING CYCLIC OLEFIN-BASED OLIGOMER OR OLEFIN-BASED POLYMER BY USING SAME KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2025-06-12 US disclosed
WO-2024043542-A1 CATALYST COMPOSITION FOR CYCLIC OLEFIN POLYMERIZATION, AND METHOD FOR PREPARING CYCLIC OLEFIN-BASED OLIGOMER OR OLEFIN-BASED POLYMER BY USING SAME 경북대학교 산학협력단 2024-02-29 WO disclosed
EP-3597649-B1 COMPOSITIONS CONTAINING SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS DART NEUROSCIENCE CAYMAN LTD (KY) 2021-10-13 EP disclosed
EP-3536319-A1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS MERCK SHARP & DOHME CORP. (US) 2019-09-11 EP disclosed
EP-3134413-B1 SUBSTITUTED [1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL COMPOUNDS AS PDE2 INHIBITORS DART NEUROSCIENCE CAYMAN LTD (KY) 2019-09-11 EP disclosed
US-20180093960-A1 METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2018-04-05 US disclosed
US-20180093960-A1 METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2018-04-05 US disclosed
EP-3083584-A1 NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS Sunshine Lake Pharma Co., Ltd. (CN) 2016-10-26 EP disclosed
WO-2015090232-A1 NITROGENOUS HETEROCYCLIC DERIVATIVES AND THEIR APPLICATION IN DRUGS SUNSHINE LAKE PHARMA CO., LTD. (CN) 2015-06-25 WO disclosed
EP-1737840-A1 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF Sanofi-Aventis (FR) 2007-01-03 EP disclosed
WO-2005103033-A1 1-AMINO-PHTHALAZINE DERIVATIVES, THE PREPARATION AND THE THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2005-11-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180093960-A1 METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND LDLR, APOB, NR1H2 KMT2A 4002/4885CHKA 1648/4885HRH3 4475/4885
US-20250186981-A1 CATALYST COMPOSITION FOR CYCLIC OLEFIN POLYMERIZATION, AND METHOD FOR PREPARING CYCLIC OLEFIN-BASED OLIGOMER OR OLEFIN-BASED POLYMER BY USING SAME PPOX, COG7, ODC1 KMT2A 3802/4885CHKA 1126/4885HRH3 3813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.