Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5806322 | 0.85 | HPGD (0.51) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL8171973 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL11221012 | 0.78 | ALDH1A1 (0.47) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL7594739 | 0.77 | MAPK1 (0.40) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL5194222 | 0.75 | ALDH1A1 (0.43) | ALDH1A1HPGDKDM4EMAPTTSHR | |
| SCHEMBL14694002 | 0.74 | MAPK1 (0.42) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL9768377 | 0.74 | ADRA2A (0.50) | ALDH1A1HPGDKDM4EMAPTMAPK1 | |
| SCHEMBL4598965 | 0.74 | MEN1 (0.51) | ALDH1A1MAPTTSHRMEN1KMT2A | |
| SCHEMBL4796316 | 0.73 | TSHR (0.47) | ALDH1A1HPGDKDM4EMAPTTSHR | |
| SCHEMBL3594662 | 0.73 | TSHR (0.53) | ALDH1A1HPGDKDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809626-A2 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | Neurogen Corporation (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006044174-A9 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | NEUROGEN CORP (US) | 2006-07-20 | — | — | WO | disclosed |
| WO-2006044174-A2 | ARYL SUBSTITUTED 8-AZABICYCLO[3.2.1]OCTANE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR | NEUROGEN CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |