Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | SLC6A15 | Q9H2J7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5197000 | 0.87 | DPP4 (0.43) | GPR119CHRM2CHRM1SMN1; SMN2LMNA | |
| SCHEMBL3941601 | 0.84 | OPRM1 (0.51) | L3MBTL1PRMT5WDR77 | |
| SCHEMBL5223968 | 0.81 | CHRM2 (0.49) | GPR119CHRM2CHRM1SMN1; SMN2LMNA | |
| SCHEMBL4898763 | 0.81 | GPR119 (0.46) | GPR119MAPTKDM4E | |
| SCHEMBL5310120 | 0.81 | GPR119 (0.44) | GPR119CHRM2CHRM1HRH1SLC6A15 | |
| SCHEMBL5228645 | 0.81 | CHRM2 (0.48) | GPR119CHRM2CHRM1SMN1; SMN2LMNA | |
| SCHEMBL5198989 | 0.80 | CHRM2 (0.46) | GPR119CHRM2CHRM1SMN1; SMN2LMNA | |
| SCHEMBL3940080 | 0.78 | OPRM1 (0.46) | PRMT5WDR77 | |
| SCHEMBL4891099 | 0.78 | HCAR1 (0.44) | GPR119 | |
| SCHEMBL5198338 | 0.78 | CHRM2 (0.51) | GPR119CHRM2CHRM1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814873-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006038006-A2 | 5-SULFONYL-1-PIPERIDINYL SUBSTITUTED INDOLE DERIVATIVES AS 5-HT6 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF CNS DISORDERS | GLAXO GROUP LIMITED (GB) | 2006-04-13 | — | — | WO | disclosed |