Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.52 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.42 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.42 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1121851 | 0.77 | BRAF (0.72) | RAB9ABRAFFYNSMN1; SMN2NPC1 | |
| SCHEMBL16504459 | 0.76 | KDM5A (0.59) | KDM5AKDM4DKDM4CKDM5BKDM3A | |
| SCHEMBL11163471 | 0.72 | SMN1; SMN2 (0.50) | KDM5AKDM4DKDM4CKDM5BKDM3A | |
| SCHEMBL3080697 | 0.71 | KDM5A (0.55) | KDM5AKDM4DKDM4CKDM5BKDM3A | |
| SCHEMBL11180492 | 0.71 | KDM5A (0.55) | KDM5AKDM4DKDM4CKDM5BKDM3A | |
| SCHEMBL6656588 | 0.71 | BRAF (0.62) | MAPTBRAFSMN1; SMN2POLB | |
| SCHEMBL11168902 | 0.71 | RAB9A (0.56) | KDM5AKDM4DKDM4CKDM5BKDM3A | |
| SCHEMBL5674663 | 0.70 | HSD17B10 (0.59) | MEN1MAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL31198183 | 0.70 | HSD17B10 (0.59) | MEN1MAPTKMT2ASMN1; SMN2POLB | |
| SCHEMBL1782451 | 0.69 | IDO1 (0.44) | MEN1MAPTRAB9AKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831184-A2 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | The Wellcome Trust Limited (GB) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067466-A2 | PYRAZINES AND PYRIDINES AND DERIVATIVES THEREOF AS THERAPEUTIC COMPOUNDS | THE WELLCOME TRUST LIMITED (GB) | 2006-06-29 | — | — | WO | disclosed |