Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 3/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5198641 | 0.88 | TGFBR1 (0.37) | TGFBR1MAPK14ACVR1 | |
| SCHEMBL5198265 | 0.85 | TGFBR1 (0.39) | TGFBR1MAPK14 | |
| SCHEMBL5198955 | 0.84 | TGFBR1 (0.47) | TGFBR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5199272 | 0.83 | CNR2 (0.42) | TGFBR1CNR2MAPK14 | |
| SCHEMBL5198987 | 0.83 | TGFBR1 (0.37) | TGFBR1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5197736 | 0.82 | TGFBR1 (0.42) | TGFBR1MAPK14 | |
| SCHEMBL5200249 | 0.81 | CNR1 (0.41) | BDKRB1TGFBR1JAK2JAK1TYK2 | |
| SCHEMBL5200266 | 0.81 | TGFBR1 (0.38) | TGFBR1MAPK14 | |
| SCHEMBL5198607 | 0.80 | TGFBR1 (0.39) | TGFBR1MAPK14 | |
| SCHEMBL5198600 | 0.77 | DGAT1 (0.41) | TGFBR1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | BDKRB1 57/4885TGFBR1 40/4885JAK2 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.