Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ECE1 | P42892 | 5/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2461628 | 0.92 | TRPM8 (0.41) | TRPM8ECE1IDO1 | |
| SCHEMBL2406499 | 0.86 | HTT (0.45) | TRPM8ALDH1A1TSHRBLMHTT | |
| SCHEMBL9567968 | 0.83 | TRPM8 (0.49) | TRPM8ALDH1A1HTTECE1 | |
| SCHEMBL9567950 | 0.82 | TRPM8 (0.48) | TRPM8ALDH1A1BLMHTTECE1 | |
| SCHEMBL8802816 | 0.79 | TSHR (0.50) | ALDH1A1TSHRBLMHTTXBP1 | |
| SCHEMBL27385115 | 0.75 | TRPM8 (0.43) | TRPM8ECE1 | |
| SCHEMBL11073296 | 0.74 | ECE1 (0.45) | ALDH1A1TSHRBLMHTTXBP1 | |
| SCHEMBL21359435 | 0.74 | TSHR (0.44) | TRPM8ALDH1A1TSHRHTTECE1 | |
| SCHEMBL30644032 | 0.74 | HTT (0.48) | TRPM8ALDH1A1TSHRBLMHTT | |
| SCHEMBL5285710 | 0.74 | HTT (0.48) | TRPM8ALDH1A1TSHRBLMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799637-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | Amgen, Inc (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006036664-A1 | SUBSTITUTED SULFONAMIDOPROPIONAMIDES AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |