Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193442 | 0.96 | MAPT (0.55) | MAPTFAAHSMN1; SMN2PRKAB2PRKAG1 | |
| SCHEMBL5194086 | 0.91 | FAAH (0.62) | MAPTFAAHSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5210351 | 0.88 | FAAH (0.46) | MAPTFAAHKMT2AMEN1 | |
| SCHEMBL5191582 | 0.85 | TP53 (0.56) | MAPTFAAHPOLBPKMSMN1; SMN2 | |
| SCHEMBL5191970 | 0.81 | MAPT (0.49) | MAPTPOLBPKMSMN1; SMN2KMT2A | |
| SCHEMBL5192480 | 0.80 | SIGMAR1 (0.48) | MAPTPOLBPKMSMN1; SMN2KMT2A | |
| SCHEMBL5192582 | 0.79 | FAAH (0.50) | MAPTFAAHPOLBKMT2AMEN1 | |
| SCHEMBL5191215 | 0.79 | FAAH (0.60) | MAPTFAAHSMN1; SMN2 | |
| SCHEMBL5190010 | 0.78 | POLB (0.60) | POLBPKMSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5190799 | 0.77 | PDGFRB (0.42) | MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | claimed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | claimed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | claimed |