Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | GYS1 | P13807 | 1/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200178 | 0.83 | ELANE (0.36) | AKR1B1 | |
| SCHEMBL5199656 | 0.75 | MEP1B (0.35) | — | |
| SCHEMBL1569775 | 0.73 | CA3 (0.46) | — | |
| SCHEMBL9806449 | 0.73 | SELL (0.37) | — | |
| SCHEMBL1516538 | 0.72 | GABRA1 (0.41) | ARAKR1B1GABRA1GABRB2 | |
| SCHEMBL27823662 | 0.70 | PTGS1 (0.38) | — | |
| SCHEMBL15054797 | 0.68 | MEP1B (0.41) | — | |
| SCHEMBL5198649 | 0.68 | CYP3A4 (0.37) | ERCC1ERCC4GCGR | |
| SCHEMBL5198633 | 0.68 | ERN1 (0.34) | — | |
| SCHEMBL1829471 | 0.68 | ERN1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817296-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006057869-A1 | POTENTIATORS OF GLUTAMATE RECEPTORS | ELI LILLY AND COMPANY (US) | 2006-06-01 | — | — | WO | disclosed |