Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | STK4 | Q13043 | 2/20 | 0.35 |
| ▸ | STK3 | Q13188 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199926 | 0.90 | MAP4K1 (0.42) | MAP4K1TGFBR1THRBTYK2JAK2 | |
| SCHEMBL5200249 | 0.86 | CNR1 (0.41) | MAP4K1TGFBR1TYK2JAK2JAK1 | |
| SCHEMBL5199891 | 0.85 | CNR2 (0.49) | MAP4K1TGFBR1KDM4EALDH1A1MAPT | |
| SCHEMBL5198175 | 0.84 | BMPR1A (0.45) | TGFBR1NPC1RAB9A | |
| SCHEMBL5907460 | 0.82 | TGFBR1 (0.43) | BRD9BAZ2BTGFBR1PIM1AHR | |
| SCHEMBL5198540 | 0.80 | TGFBR1 (0.39) | TGFBR1THRBTYK2JAK2JAK1 | |
| SCHEMBL5198641 | 0.80 | TGFBR1 (0.37) | BRD9BAZ2BTGFBR1 | |
| SCHEMBL5199757 | 0.79 | JAK2 (0.42) | TGFBR1TYK2JAK2JAK1JAK3 | |
| SCHEMBL5198168 | 0.78 | TGFBR1 (0.41) | TGFBR1THRB | |
| SCHEMBL5199820 | 0.78 | TGFBR1 (0.42) | TGFBR1LRRK2THRBHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | SANKYO COMPANY, LIMITED (JP) | 2007-11-29 | — | — | US | disclosed |
| EP-1798229-A1 | SUBSTITUTED BIPHENYL DERIVATIVE | Sankyo Company, Limited (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275968-A1 | Substituted Biphenyl Derivative | COL2A1, COL1A1, FGFR3 | BRD9 376/4885BAZ2B 75/4885MAP4K1 4294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.