Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.52 |
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5203075 | 0.99 | TAAR1 (0.51) | TAAR1HTR1DHTR1BADRA1AADRA2C | |
| SCHEMBL5200810 | 0.86 | TAAR1 (0.51) | TAAR1HTR1DADRA1AADRA2CADRA2A | |
| SCHEMBL5203304 | 0.85 | TAAR1 (0.60) | TAAR1HTR1DADRA1AADRA2CADRA2A | |
| Hydrochloric Acid SCHEMBL5203153 | 0.85 | TAAR1 (0.50) | TAAR1HTR1DADRA1AADRA2CADRA2A | |
| Hydrochloric Acid SCHEMBL5203467 | 0.83 | TAAR1 (0.48) | TAAR1HTR1DHTR1BADRA1AADRA2C | |
| SCHEMBL5204270 | 0.83 | TAAR1 (0.48) | TAAR1HTR1DADRA1AADRA2CADRA2A | |
| SCHEMBL13752307 | 0.83 | HTR1D (0.50) | TAAR1HTR1DHTR1BADRA1AADRA2C | |
| SCHEMBL4992395 | 0.83 | HTR1D (0.50) | TAAR1HTR1DHTR1BADRA1AADRA2C | |
| SCHEMBL4986530 | 0.83 | ADRA1A (0.50) | TAAR1HTR1DHTR1BADRA1AADRA2C | |
| SCHEMBL2561416 | 0.83 | HTR1D (0.50) | TAAR1HTR1DHTR1BADRA1AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | claimed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | claimed |
| EP-0887346-B1 | N-Phenyl-alkylsulfonamide derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | HOFFMANN LA ROCHE (CH) | 2007-12-12 | — | — | EP | disclosed |
| EP-0887346-A2 | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives, their preparation and their use as alpha1A/1L adrenoceptor agonists | F. HOFFMANN-LA ROCHE AG (CH) | 1998-12-30 | — | — | EP | disclosed |