Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.50 |
| ▸ | HTR1B | P28222 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3726850 | 0.99 | HTR1D (0.49) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL4992395 | 0.86 | HTR1D (0.50) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL4986530 | 0.86 | ADRA1A (0.50) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL13752307 | 0.86 | HTR1D (0.50) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL4993251 | 0.84 | HTR1B (0.48) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL5200657 | 0.83 | TAAR1 (0.52) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL5203075 | 0.82 | TAAR1 (0.51) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL5201261 | 0.81 | HTR1D (0.59) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL5203869 | 0.80 | HTR1D (0.57) | HTR1DHTR1BADRA1AADRA1DADRA1B | |
| SCHEMBL5200544 | 0.78 | ADRA1A (0.48) | HTR1DHTR1BADRA1AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238115-B1 | NOVEL IMIDAZOLINYLMETHYL ARYL SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2011-11-02 | — | — | EP | disclosed |
| EP-2238115-B1 | NOVEL IMIDAZOLINYLMETHYL ARYL SULFONAMIDES | HOFFMANN LA ROCHE (CH) | 2011-11-02 | — | — | EP | disclosed |
| EP-2238115-A1 | NOVEL IMIDAZOLINYLMETHYL ARYL SULFONAMIDES | F. Hoffmann-La Roche AG (CH) | 2010-10-13 | — | — | EP | disclosed |
| WO-2009098133-A1 | NOVEL IMIDAZOLINYLMETHYL ARYL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009098133-A1 | NOVEL IMIDAZOLINYLMETHYL ARYL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197933-A1 | IMIDAZOLINYLMETHYL ARYL SULFONAMIDE | ROCHE PALO ALTO LLC | 2009-08-06 | — | — | US | disclosed |
| US-20090197933-A1 | IMIDAZOLINYLMETHYL ARYL SULFONAMIDE | ROCHE PALO ALTO LLC | 2009-08-06 | — | — | US | disclosed |
| US-20090197933-A1 | IMIDAZOLINYLMETHYL ARYL SULFONAMIDE | ROCHE PALO ALTO LLC | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197933-A1 | IMIDAZOLINYLMETHYL ARYL SULFONAMIDE | ADRA1A, ADRA1D, ADRB1 | HTR1D 31/4885HTR1B 196/4885ADRA1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.