Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 20/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702253 | 0.96 | MPO (0.62) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL25307628 | 0.91 | MPO (0.60) | MPOSLC6A4HTR2ATRPM8 | |
| SCHEMBL5637174 | 0.86 | HTR2A (0.55) | MPOSLC6A4HTR2A | |
| SCHEMBL6958283 | 0.85 | SLC6A4 (0.57) | SLC6A4HTR2ATRPM8 | |
| SCHEMBL16433177 | 0.84 | MPO (0.55) | MPOSLC6A4 | |
| SCHEMBL6949448 | 0.82 | SLC6A4 (0.54) | MPOSLC6A4HTR2A | |
| SCHEMBL27500639 | 0.81 | SLC6A4 (0.52) | MPOSLC6A4HTR2A | |
| SCHEMBL4351623 | 0.80 | MPO (0.54) | MPOSLC6A4 | |
| SCHEMBL5203147 | 0.80 | GPR84 (0.57) | — | |
| SCHEMBL3702252 | 0.80 | MPO (0.67) | MPOSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998474-B1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| EP-0993458-B1 | 3-BENZYLPIPERIDINE | MERCK PATENT GMBH (DE) | 2003-04-09 | — | — | EP | disclosed |
| CN-1093127-C | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2002-10-23 | — | — | CN | disclosed |
| US-6333339-B1 | CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS | MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) | 2001-12-25 | — | — | US | disclosed |
| US-6251908-B1 | Piperazine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2001-06-26 | — | — | US | disclosed |
| CN-1264379-A | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2000-08-23 | — | — | CN | disclosed |
| CN-1260791-A | 3-benzylpiperidine | MERCK PATENT GMBH (DE) | 2000-07-19 | — | — | CN | disclosed |
| EP-0998474-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2000-05-10 | — | — | EP | disclosed |
| EP-0993458-A1 | 3-BENZYLPIPERIDINE | MERCK PATENT GmbH (DE) | 2000-04-19 | — | — | EP | disclosed |
| WO-1999003855-A1 | PIPERAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1999-01-28 | — | — | WO | disclosed |
| WO-1998057953-A1 | 3-BENZYLPIPERIDINE | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | WO | disclosed |