SCHEMBL6949448

SCHEMBL6949448

CS(=O)(=O)OCCCCc1c[nH]c2ccccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.54
SMN1; SMN2 Q16637 2/20 0.52
CYP1A2 P05177 2/20 0.52
CYP3A4 P08684 2/20 0.52
CYP2D6 P10635 2/20 0.52
CYP2C9 P11712 1/20 0.52
CYP2C19 P33261 1/20 0.52
HTR1A P08908 4/20 0.49
KCNA5 P22460 1/20 0.49
KCNH2 Q12809 1/20 0.49
ALOX12 P18054 1/20 0.49
ALDH1A1 P00352 4/20 0.49
SSTR2 P30874 1/20 0.49
SSTR4 P31391 1/20 0.49
MAPT P10636 2/20 0.49
MEN1 O00255 1/20 0.49
LMNA P02545 1/20 0.49
KMT2A Q03164 1/20 0.49
HTR2A P28223 3/20 0.49
HTR2C P28335 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27500639 0.99 SLC6A4 (0.52) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL5338731 0.96 SLC6A4 (0.55) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL649226 0.90 HTR2A (0.53) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL7281690 0.82 NR3C1 (0.51) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL10976542 0.82 HTR1A (0.42) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL5201036 0.82 MPO (0.61) SLC6A4HTR2AMPO
SCHEMBL6958283 0.82 SLC6A4 (0.57) SLC6A4HTR1AMAPTMEN1LMNA
SCHEMBL1177062 0.81 MEN1 (0.53) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6
SCHEMBL7004146 0.80 HTR2A (0.71) SLC6A4CYP1A2CYP3A4CYP2D6HTR1A
SCHEMBL9208031 0.80 CYP19A1 (0.56) SLC6A4SMN1; SMN2CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0993458-B1 3-BENZYLPIPERIDINE MERCK PATENT GMBH (DE) 2003-04-09 EP disclosed
US-6333339-B1 CENTRAL SYSTEM DISORDERS, SCHIZOPHRENIA AND COGNITION ACTIVATORS MERCK PATENT GELLSCHAFT MIT BESCHRANKTER (DE) 2001-12-25 US disclosed
CN-1260791-A 3-benzylpiperidine MERCK PATENT GMBH (DE) 2000-07-19 CN disclosed
EP-0993458-A1 3-BENZYLPIPERIDINE MERCK PATENT GmbH (DE) 2000-04-19 EP disclosed
WO-1998057953-A1 3-BENZYLPIPERIDINE MERCK PATENT GMBH (DE) 1998-12-23 WO disclosed