SCHEMBL5201133

SCHEMBL5201133

CNC(=O)Oc1ccc2c(N)cccc2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.43
GAA P10253 3/20 0.43
MAPK1 P28482 2/20 0.43
PGR P06401 1/20 0.43
PTGS1 P23219 1/20 0.43
HSD17B10 Q99714 1/20 0.43
HTR3A P46098 1/20 0.39
TOP2A P11388 4/20 0.38
TOP2B Q02880 4/20 0.38
POLB P06746 3/20 0.37
KDM4E B2RXH2 3/20 0.37
KMT2A Q03164 2/20 0.37
GLA P06280 2/20 0.37
NPC1 O15118 1/20 0.37
LMNA P02545 1/20 0.37
HPGD P15428 1/20 0.37
PTBP1 P26599 1/20 0.37
RAB9A P51151 1/20 0.37
RCE1 Q9Y256 1/20 0.37
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5206188 0.84 HTR3A (0.40) ALDH1A1GAAMAPK1HSD17B10HTR3A
SCHEMBL5203518 0.82 KMT2A (0.41) ALDH1A1GAAMAPK1HSD17B10HTR3A
SCHEMBL5200482 0.77 TSPO (0.49) ALDH1A1HSD17B10KDM4EKMT2ANPC1
SCHEMBL31179390 0.75 HTR3A (0.46) ALDH1A1GAAPTGS1HSD17B10HTR3A
SCHEMBL3532637 0.75 HTR3A (0.46) ALDH1A1GAAPTGS1HSD17B10HTR3A
SCHEMBL4822253 0.75 BRD4 (0.47) ALDH1A1GAAMAPK1HTR3APOLB
SCHEMBL3535547 0.72 ALDH1A1 (0.45) ALDH1A1GAAHSD17B10HTR3APOLB
SCHEMBL4816736 0.71 ALDH1A1 (0.46) ALDH1A1GAAMAPK1HTR3APOLB
SCHEMBL15140305 0.70 MEN1 (0.54) ALDH1A1GAAMAPK1PGRPTGS1
SCHEMBL11772785 0.70 ALDH1A1 (0.59) ALDH1A1GAAMAPK1PGRPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1492771-B1 QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS SCHERING AG (DE) 2007-02-28 EP disclosed
EP-1492771-A1 QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 2005-01-05 EP disclosed
WO-2003082827-A1 QUINOLINE AND ISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS SCHERING AKTIENGESELLSCHAFT (DE) 2003-10-09 WO disclosed