Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | TPH1 | P17752 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201565 | 0.85 | USP30 (0.36) | UCHL1USP30GPR119GRM5 | |
| SCHEMBL5202276 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2GAACASP3CASP7CASP8 | |
| SCHEMBL3572145 | 0.81 | NR1H2 (0.43) | NR1H2NR1H3SMN1; SMN2GAAUCHL1 | |
| SCHEMBL5203615 | 0.78 | UCHL1 (0.38) | UCHL1USP30GPR119GRM5 | |
| SCHEMBL5202192 | 0.77 | UCHL1 (0.37) | UCHL1USP30GPR119GRM5 | |
| SCHEMBL4761317 | 0.72 | NR1H2 (0.46) | NR1H2NR1H3SMN1; SMN2GAACASP3 | |
| SCHEMBL12789591 | 0.71 | NR1H2 (0.59) | NR1H2NR1H3SMN1; SMN2GAACASP3 | |
| SCHEMBL8219203 | 0.71 | NR1H2 (0.59) | NR1H2NR1H3SMN1; SMN2GAACASP3 | |
| SCHEMBL12215951 | 0.71 | NR1H2 (0.59) | NR1H2NR1H3SMN1; SMN2GAACASP3 | |
| SCHEMBL23975518 | 0.70 | NR1H2 (0.58) | NR1H2NR1H3SMN1; SMN2GAACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |