Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 6/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202192 | 0.93 | UCHL1 (0.37) | UCHL1USP30CHEK2GPR119GRM5 | |
| SCHEMBL5201565 | 0.83 | USP30 (0.36) | UCHL1USP30CHEK2GPR119GRM5 | |
| SCHEMBL5201529 | 0.78 | NR1H2 (0.43) | UCHL1USP30GPR119GRM5 | |
| SCHEMBL3564331 | 0.76 | NOS2 (0.41) | USP30GPR119GRM5JAK2 | |
| SCHEMBL5204446 | 0.71 | HCRTR1 (0.37) | UCHL1USP30GRM5HCRTR1HCRTR2 | |
| SCHEMBL3564512 | 0.69 | NOS2 (0.40) | USP30GPR119GRM5 | |
| SCHEMBL5199693 | 0.68 | MAPT (0.34) | HCRTR1HCRTR2 | |
| SCHEMBL4640604 | 0.67 | AADAT (0.45) | — | |
| SCHEMBL3563497 | 0.67 | NOS2 (0.41) | GPR119 | |
| SCHEMBL25411250 | 0.66 | GPR119 (0.44) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |