Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADK | P55263 | 1/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5200449 | 0.70 | BRD4 (0.37) | FFAR1MTORADKNISCHALDH1A1 | |
| SCHEMBL3562250 | 0.68 | NPSR1 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5199466 | 0.66 | LMNA (0.46) | MTORADKNISCHALDH1A1LMNA | |
| SCHEMBL20840542 | 0.65 | SMN1; SMN2 (0.46) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL5199947 | 0.65 | HRH3 (0.35) | ALDH1A1HTTHCRTR1HCRTR2 | |
| SCHEMBL5201190 | 0.65 | MAPK14 (0.33) | ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL5200333 | 0.63 | KDM4E (0.39) | MTORADKNISCHALDH1A1ADRA2A | |
| SCHEMBL9026316 | 0.62 | NISCH (0.50) | MTORADKNISCHALDH1A1SMN1; SMN2 | |
| SCHEMBL5200348 | 0.62 | NISCH (0.34) | NISCHALDH1A1SMN1; SMN2HCRTR1HCRTR2 | |
| SCHEMBL24910869 | 0.60 | NISCH (0.41) | MTORADKNISCHALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817030-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | Kalypsys, Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006060424-A2 | INDUCIBLE NITRIC OXIDE SYNTHASE DIMERIZATION INHIBITORS | KALYPSYS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |