Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | DRD2 | P14416 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060315 | 0.86 | OPRL1 (0.41) | HTR1ADRD2HTR2AHTR2CALDH1A1 | |
| SCHEMBL4797430 | 0.81 | ROCK2 (0.37) | HTR1ADRD2ALDH1A1CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL4589568 | 0.80 | ROCK2 (0.37) | HTR1ADRD2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6921067 | 0.76 | IDE (0.41) | HTR1ADRD2CYP2C19SIGMAR1 | |
| SCHEMBL11273204 | 0.68 | HTR2C (0.46) | HTR1ADRD2HTR2AHTR2C | |
| SCHEMBL5155779 | 0.68 | PPARG (0.50) | HTR1ADRD2HTR2AHTR2CMAPT | |
| SCHEMBL29275206 | 0.67 | ESR1 (0.51) | ESR1BACE1 | |
| SCHEMBL9422688 | 0.65 | DRD2 (0.63) | HTR1ADRD2TRPV6HTR2CALDH1A1 | |
| Hydrochloric Acid SCHEMBL9305904 | 0.64 | DRD2 (0.62) | HTR1ADRD2TRPV6HTR2CALDH1A1 | |
| SCHEMBL1401419 | 0.63 | DRD2 (0.60) | HTR1ADRD2HTR2ATRPV6HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383762-B1 | TETRAHYDROPYRIDYL-ALKYL-HETEROCYCLES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SANOFI AVENTIS (FR) | 2007-06-20 | — | — | EP | claimed |