Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 1/20 | 0.41 |
| ▸ | UBE2N | P61088 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060315 | 0.83 | OPRL1 (0.41) | DRD2SIGMAR1CYP2C19DRD4GRM2 | |
| SCHEMBL6921065 | 0.78 | DRD2 (0.63) | IDEUBE2NDRD2MC4RSIGMAR1 | |
| SCHEMBL4797430 | 0.75 | ROCK2 (0.37) | DRD2SIGMAR1POLBCYP2C19DRD4 | |
| SCHEMBL11273204 | 0.71 | HTR2C (0.46) | DRD2HTR1A | |
| SCHEMBL1821251 | 0.65 | HTR7 (0.51) | DRD2DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL9486649 | 0.65 | HTR7 (0.50) | DRD2DRD4HTR1A | |
| SCHEMBL6590789 | 0.64 | SLC18A2 (0.46) | MC4RSIGMAR1SLC18A2 | |
| SCHEMBL10475673 | 0.64 | DRD2 (0.65) | DRD2SIGMAR1DRD4GRM2 | |
| SCHEMBL30387904 | 0.63 | HTR2C (0.37) | HTR1A | |
| SCHEMBL7951503 | 0.61 | ADRA1D (0.48) | SIGMAR1SLC18A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357928-A4 | A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME | NEW RIVER PHARMACEUTICALS INC (US) | 2004-12-29 | — | — | EP | disclosed |
| EP-1357928-A2 | A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME | New River Pharmaceuticals Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2003020200-A2 | A NOVEL PHARMACEUTICAL COMPOUND AND METHODS OF MAKING AND USING SAME | NEW RIVER PHARMACEUTICALS INC. (US) | 2003-03-13 | — | — | WO | disclosed |